@JSU Zack I think
@NavyHog is right, the initial adjustment is a bit tough especially with the talent gap. I think you have a good grasp at what you want to do and what is going to happen, but the talent isn't allowing you to do what you want to do and you might not be sure how to account for that within the framework of the game.
Defense is tough in this game, in part because everything is backwards. I know the real football common sense is to be in a 46, load up the box vs run heavy sets but that just doesn't work. Those defenses never seem to set the edge and you end up allowing a bunch of perimeter runs. I would also as if you're in man or zone? Man defense in this game is garbage vs the run, but most of the blitzes are man blitzes. Honestly, I do the best against the run by just sitting in Cover 2 or Cover 3 and coming up in aggressive run support with the FS.
Unfortunately, sometimes you have to work against conventional football knowledge to make things work here. Especially defensively. I've essentially dumbed down my defense to 4 play calls. Cover 2 Invert, Cover 3, Cover 6 and typically one or two blitzes. I can get to all 4 calls via audibles and I keep the same base 11 on the field pretty much all game.
I have a handful of emergency plays/formations on defense to go to against people running something exotic, against
@NavyHog I found myself in a Bear front to account for his option game. Any time I play people who use a bunch of 3x1 formations, I find myself in regular Nickel sets a bunch.
Just have to know how the defense reacts to and aligns to certain formations and sets.