DanishDonut0
Well-Known Member
Has there ever been a study of the general population? I was thinking about this today. Studies like these look bad. But they are skewed pretty badly as well. Brains donated by people who think their loved ones had issues. Even among NFL players this doesn't give us the whole picture. What is the rate of CTE among the general population? Is it rare or is it more common than we believe? Doing some searching on google journalists throw out 3-4 times more likely than the general population. But I cant find any info on where they derive this information.
Of course there is a lot further to go but I don't see how this study looks bad. It is the largest cohort for CTE and science is made in steps. Previous largest was 48 athletes (McKee et al, 2009). If you actually read the NYT article...
About 1,300 former players have died since the B.U. group began examining brains. So even if every one of the other 1,200 players had tested negative — which even the heartiest skeptics would agree could not possibly be the case — the minimum C.T.E. prevalence would be close to 9 percent, vastly higher than in the general population.
And regarding your other questions, from a write up on the study:
Traumatic brain injury (TBI) is a major public health concern, affecting an estimated 10 million people worldwide per year and more than 40% of US residents over the course of a lifetime. Mild TBI, also referred to as concussion, is defined as blunt, nonpenetrating head trauma associated with transient symptoms (eg, headache, nausea, dizziness, visual changes, confusion, or difficulty concentrating) and accounts for more than 80% of all TBI cases. Beyond the morbidity of the immediate trauma, patients who experience mild TBI are at increased risk of developing neurological and psychiatric disorders later in life. The majority of TBI is caused by motor vehicle crashes and falls, although brain injuries also occur during participation in contact sports, with an estimated 1.6 million to 3.8 million sports-related concussions occurring in the United States per year.
The diagnosis of CTE in the present study was made blinded to clinical information, applying recently published consensus criteria developed by a panel of experts convened by the National Institutes of Health.
As the investigators acknowledge, such a sample is likely to be biased to include more impaired individuals who experienced significant neuropsychiatric decline during life, thus prompting their family members to pursue brain donation.
(Advances and Gaps in Understanding Chronic Traumatic Encephalopathy From Pugilists to American Football Players - Gil D. Rabinovici 2017)